Complete Health, Inc. - Proactive Health Consulting Since 1976

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Depression Not Likely Serotonin Deficiency

I actually thought this was old news, but a new study published in the journal ACS Chemical Neuroscience showed that low serotonin appears to have no effect on mood (in other words, low serotonin doesn't correlate to depression).  The scientists did the study because previous research has shown that about 60 to 70% of people who take drugs to increase serotonin levels are still depressed.  So if more and more data is suggesting that low serotonin is not the cause, what might be the cause?  As I've blogged about previously, it appears that low-level inflammation in the brain may be the culprit.  Other research suggests a role for high cortisol levels and imbalances in the HPA (hypothalamus/pituitary/adrenal) axis.  Given this information, lowering inflammation would seem an obvious thing to do, and there is some evidence that avoiding gluten might help (in this study, gluten sensitivity was specifically correlated with depression).  IMPORTANT:  If you are currently taking antidepressant medication, do not discontinue that or any other medication without talking to your doctor.
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